How Does Ketamine Therapy Work for Anxiety?

Ketamine, once primarily known as a dissociative anesthetic, has gained recognition for its rapid-acting effects in treating mental health conditions, particularly anxiety disorders. For individuals with treatment-resistant anxiety, ketamine infusion therapy offers a promising alternative. According to a PMC study, single doses of ketamine have demonstrated rapid and sustained anxiolytic effects, lasting up to a week in patients with refractory anxiety disorders.

What Is Ketamine Therapy?

Ketamine therapy involves the administration of ketamine through intravenous (IV) infusion under medical supervision. Initially used for anesthesia, ketamine’s unique effects on NMDA receptors and neurotransmitter activity have shown potential in managing chronic anxiety, PTSD, and other mood disorders.

Learn more about the basics of ketamine therapy in our post on What is Ketamine Therapy and Where to Get It.

How Does Ketamine Work for Anxiety?

NMDA Receptor Antagonism

Ketamine works by blocking NMDA receptors, preventing the excessive release of glutamate—a neurotransmitter associated with excitatory neural activity. This blockade helps disrupt negative thought patterns, reducing the intensity of anxious thoughts.

Glutamate Release and Synaptic Rewiring

Following NMDA receptor inhibition, ketamine triggers a surge in glutamate release, activating AMPA receptors. This activation fosters synaptic plasticity, allowing the brain to form new neural connections. For individuals with anxiety, this “reset” effect can reduce rumination and anxious thought loops.

Default Mode Network (DMN) Regulation

The Default Mode Network (DMN) is a brain network associated with self-referential thoughts and rumination. In people with chronic anxiety, the DMN can become overactive, leading to persistent worry and negative thought cycles. Ketamine helps normalize DMN activity, promoting cognitive flexibility and reducing self-focused thinking.

BDNF Production and Neurogenesis

Ketamine’s impact extends to the growth of new neurons, facilitated by increased levels of Brain-Derived Neurotrophic Factor (BDNF). BDNF promotes neurogenesis in the prefrontal cortex and hippocampus, two regions heavily impacted by stress and anxiety. By fostering neural growth, ketamine can repair stress-damaged brain regions, improving emotional regulation.

Anti-Inflammatory Effects

Chronic anxiety is often associated with elevated inflammation levels. Ketamine’s ability to reduce pro-inflammatory cytokines helps protect neurons and alleviate symptoms of anxiety. This neuroprotective effect also contributes to better cognitive function and mood stability.

What to Expect During a Ketamine Therapy Session for Anxiety

Initial Consultation: Clients undergo a comprehensive health assessment to determine their eligibility for ketamine therapy. Medical history, current medications, and treatment goals are reviewed.
Infusion Process: A licensed provider administers the ketamine infusion through an IV catheter. The infusion typically lasts 60 minutes, during which clients are monitored closely for vital signs and comfort levels.
Sensations During the Infusion: Some clients report feeling dissociation or mild euphoria, while others experience a sense of mental clarity or calm.
Post-Session Monitoring: After the infusion, clients are monitored for any lingering effects and given time to rest before being discharged.

Potential Side Effects and Safety Considerations

Ketamine therapy is generally well-tolerated, especially when administered in a controlled, medical setting. Some clients may experience temporary sensations during or after the session, including:

• Mild nausea

• A sense of mental disconnection or deep introspection

• Feeling tired or relaxed afterward

At Biofuse, every ketamine session is closely monitored by licensed medical professionals to ensure your comfort, safety, and the most effective therapeutic experience.

Client Experiences and Success Stories

Grand Rapids, MI:
“Ketamines’s rapid effects on my anxiety were unbelievable. I felt more at ease within hours, and the feeling lasted for days.” — Jenna, Grand Rapids

Traverse City, MI:
“I was skeptical, but after just two sessions, I could finally relax without that constant sense of dread. My therapist recommended Biofuse, and I’m so glad I gave it a shot.” — Mark, Traverse City

Portage, MI:
“The therapy was intense but incredibly effective. I felt a mental reset that helped me see things more clearly.” — Rachel, Portage

Boise, ID:
“For the first time in years, I felt like I could breathe without that tightness in my chest. It’s been a game-changer for my anxiety.” — Chris, Boise

Where to Get Ketamine Therapy for Anxiety Near You

Biofuse offers medically supervised ketamine infusion therapy at multiple locations, providing targeted relief for anxiety, PTSD, and other mood disorders.

Ketamine Therapy in Grand Rapids, Michigan

465 Fuller Ave NE Suite C, Grand Rapids, MI 49503
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Final Takeaway: Is Ketamine Therapy Right for You?

For individuals struggling with treatment-resistant anxiety, ketamine therapy offers a rapid and effective alternative. By modulating neurotransmitter activity and promoting neural growth, ketamine can provide immediate relief and long-term cognitive benefits.

Book your Ketamine Therapy session today to learn how Biofuse’s personalized treatments can help you manage anxiety effectively.